Epithalon

Helps slow down the aging process and improve overall health and longevity. It also increases resistance to emotional stress and improves sleep.

Active ingredient:

n/a

Molecular formula:

C16H24N4O10

Molecular weight:

432.4 g/mol

Intake:

Injection

Epithalon

Active ingredient:

n/a

Molecular formula:

C16H24N4O10

Molecular weight:

432.4 g/mol

Intake:

Injection

What is

Epithalon

Epithalon (also known as Epitalon or Epithalamin) is a synthetic peptide that is composed of four amino acids: Ala-Glu-Asp-Gly. It was originally isolated from the pineal gland of cattle, but the synthetic form is now used for research and potential therapeutic applications.

Epithalon works by stimulating the production of telomerase, an enzyme that helps to maintain the length of telomeres – the protective caps on the ends of our chromosomes. Telomeres naturally shorten as we age, which can lead to cellular damage and aging-related diseases. By stimulating telomerase production, epithalon may help to slow down the aging process and improve overall health and longevity.

In addition to its potential anti-aging effects, epithalon has also been studied for its potential therapeutic applications in the treatment of certain medical conditions, such as cancer and metabolic disorders. Some studies have shown that epithalon may have anti-tumor effects and may help to improve glucose metabolism and insulin sensitivity.

Benefits

  • Promotes deeper sleep
  • Exhibit antibacterial properties
  • Improves skin health and appearance
  • Heals injured and deteriorating muscle cells
  • Can increase resistance to emotional stress
  • Increases lifespan by lengthening telomeres in human cells
  • Delays and prevents of age-related diseases such as cancer, heart disease, and dementia
  • Restores and normalizes melatonin levels in those who have lost some pineal function due to aging
  • Acts as an antioxidant by reducing lipid oxidation and ROS (Reactive oxygen species) along with normalizing T cell function

Protocols

Provided as a 50mg lyophilized vial

  • Initiation: Epithalon therapy is initiated to support anti-aging processes, enhance telomerase activity, and improve overall health by modulating the pineal gland.
  • Initial Dose: Begin with 5 mg (0.1 ml or 10 units) subcutaneously every 2-3 days for the first two weeks to assess tolerance and minimize potential side effects.
  • Titration: If well tolerated, increase the dose to 10 mg (0.2 ml or 20 units) subcutaneously every 2-3 days after the initial two-week period.
  • Maintenance: Maintain the dose at 10 mg (0.2 ml or 20 units) subcutaneously every 2-3 days for a total of 50 mg (5 injections total). The treatment can be repeated one more time per year after a 6-month interval (2 times per year).
  • Duration: Epithalon is administered every 2-3 days.
  • Weeks 1-2: 5 mg (0.1 ml or 10 units) of Epithalon every 2-3 days
  • Week 3 and onwards: 10 mg (0.2 ml or 20 units) of Epithalon every 2-3 days for a total of 50 mg (5 injections total)

*Provided as a standard protocol, dose may vary depending on the condition of the patient.
*The dosage of Epithalon may be adjusted based on the individual’s response, medical history, and specific treatment goals.

  • Known hypersensitivity to Epithalon or any component of the formulation.
  • Not recommended for use during pregnancy or breastfeeding unless specifically advised by a healthcare provider.
  • Patients with severe autoimmune diseases should consult with their healthcare provider before starting this treatment.
  • Avoid using other anti-aging therapies concurrently without professional advice to prevent potential interactions.

  • Regular monitoring of overall health and well-being to assess the effectiveness of the treatment.
  • Periodic assessments to check for any adverse effects and to adjust the treatment as necessary.
  • Consultation with a healthcare professional before starting Epithalon to ensure it is appropriate for the patient’s health condition.
  • Patients should maintain a healthy lifestyle, including proper diet and exercise, to support the effectiveness of the treatment​

Procedure

Reconstitution

  • Draw 1 ml of sterile water for injection into a syringe.
  • Inject the sterile water into a vial containing 50 mg of Epithalon peptide.
  • Gently swirl the vial until the peptide is fully dissolved.

  • Remove the cap from a tuberculin syringe.
  • Draw the reconstituted Epithalon solution into the syringe to the required dosage (0.1 ml or 10 units initially, 0.2 ml or 20 units after titration).
  • Clean the selected injection site with an alcohol swab.
  • Pinch the sanitized skin and insert the needle at a 90-degree angle.
  • Administer the injection subcutaneously every 2-3 days.

  • Store the remaining Epithalon solution in the refrigerator at 2-8°C.
  • Before the next use, clean the vial top with an alcohol swab.
  • Use a new syringe for each administration.
  • Ensure to rotate injection sites (abdomen, thigh, or upper arm) to minimize skin irritation.

Clinical Research

Study:

Epithalon for Anti-Aging and Longevity

Source:

Peptide Society, Peptides.org, MDPI

Results:

Epithalon (also known as Epitalon or AEDG) is a synthetic tetrapeptide composed of the amino acids alanine, glutamic acid, aspartic acid, and glycine. It has been studied extensively for its potential anti-aging and longevity benefits. Developed in the 1980s by Professor Vladimir Khavinson at the St. Petersburg Institute of Bioregulation and Gerontology, Epithalon has shown promise in various clinical settings.

Epithalon upregulates telomerase activity, an enzyme that maintains and elongates telomeres—the protective caps at the ends of chromosomes. By preventing telomere shortening, Epithalon helps in maintaining the integrity of DNA during cell division, thus playing a crucial role in delaying the aging process and enhancing cellular longevity.

Epithalon is generally well-tolerated with a favorable safety profile. Reported side effects are minimal and include mild injection site reactions. There is no significant evidence of toxicity, making Epithalon a promising candidate for anti-aging therapies.

Peptide Society, 2018; Peptides.org, 2023; MDPI, 2020.

Read More: https://peptidesociety.org/wp-content/uploads/2018/07/Epithalon-Monograph-Final.pdf, https://www.peptides.org/, https://www.mdpi.com/25030609

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