AOD-9604

This anti-obesity drug is developed to address obesity and assist individuals in their weight loss efforts.

Active ingredient:

hGH

Molecular formula:

C78H123N23O23S2

Molecular weight:

1815.12 g/mol

Intake:

Injection

AOD-9604

Active ingredient:

hGH

Molecular formula:

C78H123N23O23S2

Molecular weight:

1815.12 g/mol

Intake:

Injection

What is

AOD-9604

AOD-9604 is a synthetic peptide that is derived from human growth hormone (HGH). It has been shown to have potential therapeutic effects on a range of conditions, including arthritis. Studies have shown that AOD-9604 can help reduce inflammation and joint damage in animal models of arthritis. In one study, AOD-9604 was shown to decrease the production of pro-inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-α) and interleukin-1 beta (IL-1β), in rats with rheumatoid arthritis. Another study found that AOD-9604 can promote the regeneration of cartilage tissue in vitro.

In addition to its anti-inflammatory effects, AOD-9604 has been shown to have a positive effect on the metabolism of cartilage tissue. It has been shown to stimulate the production of type II collagen, which is a key component of cartilage tissue, and to inhibit the production of enzymes that can break down cartilage.Furthermore, AOD-9604 has been shown to be safe and well-tolerated in clinical trials. In one study, AOD-9604 was shown to improve joint function and reduce pain in patients with osteoarthritis.

Benefits

  • Helps reduce body fat​
  • Reduces inflammation and promotes tissue repair.
  • Demonstrated to be safe and well-tolerated in clinical trials​
  • May improve joint health, beneficial for osteoarthritis and other musculoskeletal issues​

Protocols

Provided as a 5mg lyophilized vial

  • Initiation: AOD-9604 therapy is initiated at a lower dose to promote tolerance and reduce potential side effects.
  • Initial Dose: Begin with 0.25 mg (0.1 ml or 10 units) subcutaneously twice daily (BID) for the first two weeks.
  • Titration: If well tolerated, increase the dose to 0.5 mg (0.2 ml or 20 units) subcutaneously twice daily after the initial two-week period.
  • Maintenance: Continue with the increased dose of 0.5 mg (0.2 ml or 20 units) subcutaneously twice daily for ongoing support in weight management and metabolic enhancement.
  • Duration: AOD-9604 is administered twice daily.
  • Weeks 1-2: 0.25 mg (0.1 ml or 10 units) of AOD-9604 twice daily
  • Week 3 and onwards: 0.5 mg (0.2 ml or 20 units) of AOD-9604 twice daily

*The dosage of AOD-9604 may be adjusted based on the individual’s response, medical history, and specific treatment goals.

  • Known hypersensitivity to AOD-9604 or any component of the formulation.
  • Not recommended for use during pregnancy or breastfeeding unless specifically advised by a healthcare provider.

  • Regular monitoring of weight and body composition to assess the effectiveness of the treatment.
  • Periodic blood tests to check for any adverse effects and to adjust the treatment as necessary.

Procedure

Reconstitution

  • Draw 2 ml of sterile water into a syringe.
  • Inject the sterile water into a vial containing 5 mg of AOD-9604 peptide.
  • Gently swirl the vial until the peptide is fully dissolved.

 

  • Remove the cap from a tuberculin syringe.
  • Draw the reconstituted AOD-9604 solution into the syringe to the required dosage (0.1 ml or 10 units initially, 0.2 ml or 20 units after titration).
  • Clean the selected injection site with an alcohol swab.
  • Pinch the sanitized skin and insert the needle at a 90-degree angle.
  • Administer the injection subcutaneously.
  • Repeat the above steps for the second daily dose.

  • Store the remaining AOD-9604 solution in the refrigerator at 2-8°C.
  • Before the next use, clean the vial top with an alcohol swab.
  • Use a new syringe for each administration.
  • Ensure to rotate injection sites (abdomen, thigh, or upper arm) to minimize skin irritation.

Clinical Research

Study:

AOD-9604 and Weight Loss

Source:

Journal of Endocrinology & Metabolism, Peptide Basics, Peptides Institute

Results:

AOD-9604, a peptide fragment derived from human growth hormone (hGH), has been investigated for its potential in weight loss and fat reduction. The peptide mimics the action of hGH by stimulating lipolysis (the breakdown of fats) and inhibiting lipogenesis (the formation of fat). Clinical trials have shown mixed results regarding its efficacy in treating obesity. Some studies have indicated significant reductions in body weight and body fat percentage without affecting lean muscle mass, while others have not found substantial effects.

A randomized controlled trial revealed that participants who received AOD-9604 experienced notable reductions in body weight and body fat percentage compared to those who received a placebo. These improvements were accompanied by either preservation or an increase in lean body mass. The peptide was generally well-tolerated, with mild and transient side effects like injection site reactions, headache, and fatigue. No serious adverse events were reported during the trial, suggesting a favorable safety profile for AOD-9604.

Leal D., Sánchez C., Bascuñán K., Canessa S., del Sol M. "AOD-9604 for the Treatment of Obesity: A Review." Journal of Endocrinology & Metabolism, 2023.

Articles

AOD 9604 Peptide: Research in Lipolysis, Cell Regeneration, and Cancer

AOD 9604 peptide, a synthetic analog of growth hormone (HGH), has emerged as a promising research agent in the realm of obesity and weight.

The Effects of Human GH and Its Lipolytic Fragment (AOD9604) on Lipid Metabolism

Both human GH (hGH) and a lipolytic fragment (AOD9604) synthesized from its C-terminus are capable of inducing weight loss and increasing lipolytic sensitivity

Doctor's Reviews

AOD-9604 A Weight Loss Peptide | Dr. Jones, DC

AOD-9604 is a peptide that aids in lasting weight loss by mobilizing body fat and protecting muscle mass. It is important to maintain muscle mass during weight loss as it is metabolically active and improves insulin sensitivity.

In Depth AOD 9604 Peptide Review

AOD 9604 Peptide is a cutting-edge fat metabolism treatment. Dr. Brian Anderson discusses how AOD 9604 works and more.

AOD 9604 Fat-Burning Peptide Therapy: Benefits, Dosage, & Side Effects | EVOLVE Telemedicine

AOD 9604 is a fat-burning peptide that helps to boost metabolism, lose weight, and assist with bone and cartilage repair. Learn more about the benefits, typical dosage, and side effects of AOD 9604 peptide therapy with Justin Hokams, Senior Patient Care Coordinator at EVOLVE.

AOD 9604 | A Weight Loss Peptide

AOD 9604 can stimulate the pituitary gland, which can burn body fat and boost metabolism. AOD is a synthetic analog of human growth hormone. It imitates the way natural growth hormone regulates fat metabolism which helps people lose weight and combat obesity.